Physical exercise is recommended for the prevention and treatment of osteoporosis. The present study evaluated the influence of WBV exercise on the bone formation and bone remodeling in an ovariectomized animal model.

The aim of this study is to investigate potential possibility for activation of bone formation and decrease of bone loss while whole body vibration exercise(frequency: 45Hz, vertical acceleration: 0.3g, 5 days/wk, for 12 wks) was performed. OPG concentration, RANKL concentration and RANKL/OPG ratio from bone marrow stromal cell were evaluated and DXA from the femur bone was measured. The Sprague-Dawley rats have been divided into 4 groups (Sham-operated control; Sham-operated WBV exercise; OVX-operated control; OVX-operated WBV exercise).

To compare the 4 groups(2x2) statistically, two-way ANOVA was used. Statistical significant value was p<.05.

Vibrating exercise groups showed significantly higher OPG concentration(p<.001), RANKL concentration(p<.05), BMD(p<.001), BMC (p<.001) and bone area(p<.01) values compared to control groups. The other side RANKL/OPG ratio was lower in WBV exercise groups(p<.05) significantly.

These present results indicate that WBV exercise is effective method for activating bone formation and preventing early post-ovariectomy bone loss. These also can be explained that WBV exercise increase

bone mass and bone strength in an animal model.